Chemical characterization of the milk oligosaccharides of some Artiodactyla species including giraffe (Giraffa camelopardalis), sitatunga (Tragelaphus spekii), deer (Cervus nippon yesoensis) and water buffalo (Bubalus bubalis)

Author(s)Yuri Mineguchi, Midori Miyoshi, Epi Taufik, Ayumi Kawamura, Takuya Asakawa, Isao Suzuki, Kousaku Souma, Michiko Okubo, Tadao Saito, Kenji Fukuda, Sadaki Asakuma and Tadasu Urashima
Year Published2018
JournalGlycoconjugate Journal
Page Numbers561–574
Size1.45 MB
Abstract:

Mammalian milk/colostrum usually contains oligosaccharides along with the predominant disaccharide lactose. It has been found that the number and identity of these milk oligosaccharides varies among mammalian species. Oligosaccharides predominate over lactose in the milk/colostrum of Arctoidea species (Carnivora), whereas lactose predominates over milk oligosaccharides in Artiodactyla including cow, sheep, goat, camel, reindeer and pig. To clarify whether heterogeneity of a variety of milk oligosaccharides is found within other species of Artiodactyla, they were studied in the milk of giraffe, sitatunga, deer and water buffalo. The following oligosaccharides were found: Neu5Ac(α2–3)[GalNAc(β1–4)]Gal(β1–4)Glc (GM2 tetrasaccharide), and Gal(α1–3)Gal(β1–4)Glc (isoglobotriose) in giraffe milk; Neu5Ac(α2–3)Gal(β1–4)Glc (3’-SL), Neu5Ac(α2–6)Gal(β1–4)Glc (6’-SL), Gal(α1–4)Gal(β1–4)Glc (globotriose) and isoglobotriose in sitatunga colostrum; Gal(β1–3)Gal(β1–4)Glc (3′-GL), Gal(β1–6)Gal(β1–4)Glc (6′-GL), isoglobotriose, Gal(β1–4)GlcNAc(β1–3)Gal(β1–4)Glc (lacto-N-neotetraose, LNnT), Gal(β1–4)Glc-3’-O-SO3 (3’-O-lactose sulphate) in deer milk; 3′-GL, isoglobotriose and Gal(β1–3)Gal(β1–3)Gal(β1–4)Glc (3′,3″-digalactosyllactose, DGL) in water buffalo colostrum. Thus it was shown that the milk oligosaccharides are heterogeneous among these Artiodactyla species.

Keywords: Milk oligosaccharides, Giraffe, Sitatunga, Deer, Water buffalo, Artiodactyla

Authors: Yuri Mineguchi, Midori Miyoshi, Epi Taufik, Ayumi Kawamura, Takuya Asakawa, Isao Suzuki, Kousaku Souma, Michiko Okubo, Tadao Saito, Kenji Fukuda, Sadaki Asakuma and Tadasu Urashima

Journal: Glycoconjugate Journal


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