Complete genomic sequence analyses of the first group A giraffe rotavirus reveals close evolutionary relationship with rotaviruses infecting other members of the Artiodactyla.

Author(s)Helen O’Shea, Emily Mulherin, Jelle Matthijnssens, Matthew McCusker, P. J. Collins, Olivia Cashman, Lynda Gunn, Marijke E. Beltman and Séamus Fanning
Year Published2014
JournalVeterinary Microbiology
Page Numbers151-156
Size684.37 KB
Abstract:

Group A Rotaviruses (RVA) have been established as significant contributory agents of acute gastroenteritis in young children and many animal species. In 2008, we described the first RVA strain detected in a giraffe calf (RVA/Giraffe-wt/IRL/GirRV/2008/G10P[11]), presenting with acute diarrhoea. Molecular characterisation of the VP7 and VP4 genes revealed the bovine-like genotypes G10 and P[11], respectively. To further investigate the origin of this giraffe RVA strain, the 9 remaining gene segments were sequenced and analysed, revealing the following genotype constellation: G10-P[11]-I2-R2-C2-M2-A3-N2-T6-E2-H3. This genotype constellation is very similar to RVA strains isolated from cattle or other members of the artiodactyls. Phylogenetic analyses confirmed the close relationship between GirRV and RVA strains with a bovine-like genotype constellation detected from several host species, including humans. These results suggest that RVA strain GirRV was the result of an interspecies transmission from a bovine host to the giraffe calf. However, we cannot rule out completely that this bovine-like RVA genotype constellation may be enzootic in giraffes. Future RVA surveillance in giraffes may answer this intriguing question.

Keywords: Group A Rotavirus, Giraffe, Complete genome analyses

Authors: Helen O’Shea, Emily Mulherin, Jelle Matthijnssens, Matthew McCusker, P. J. Collins, Olivia Cashman, Lynda Gunn, Marijke E. Beltman and Séamus Fanning

Journal: Veterinary Microbiology

 


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