Fatal Herpesvirus Encephalitis in a Reticulated Giraffe (Giraffa camelopardalis reticulata)

Author(s)M. J. Hoenerhoff, E. B. Janovitz, L. K. Richman, D. A Murphy, T. C. Butler, M. Kiupel
Year Published2006
JournalVeterinary Pathology Online
Page Numbers1-5
Size472.32 KB

Fatal meningoencephalitis caused by equine herpesvirus-1 (EHV-1) was diagnosed in a reticulated giraffe (Giraffa camelopardalis reticulate). The giraffe died following a history of stumbling, incoordination, and abdominal pain. Gross examination of the brain revealed asymmetric edema and red-brown discoloration, predominantly within the telencephalon. Microscopically, there was perivascular lymphohistiocytic cuffing, multifocal gliosis, and neuronal necrosis in the cerebrum. Necrotic neurons contained acidophilic intranuclear inclusions. EHV-1 was isolated from the brain of the giraffe, and polymerase chain reaction was positive on sections of the brain. Immunohistochemistry using an EHV-1–specific antibody identified positive staining in neurons, astrocytes, and endothelial cells. The giraffe had been housed with a group of zebras that were serologically positive for EHV-1 and suspected as the source of infection. This raises concerns for cross-species transmission of EHV-1 when housing equids together with other species in zoologic collections.

Keywords: Equine herpesvirus-1; Immunohistochemistry; Meningoencephalitis; Polymerase chain reaction; Reticulated giraffe
Authors: M. J. Hoenerhoff, E. B. Janovitz, L. K. Richman, D. A Murphy, T. C. Butler, M. Kiupel
Journal: Veterinary Pathology Online

Terms and Conditions: Any PDF files provided by the GRC are for personal use only and may not be reproduced. The files reflect the holdings of the GRC library and only contain pages relevant to giraffe study, and may not be complete. Users are obliged to follow all copyright restrictions.